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University of Florida
Myself Dr.Syed Muzeeb an experienced DMPK and clinical Pharmacology Scientist currently working as post-doctoral Associate with Prof Hartmut Derendorf, Department of Pharmaceutics, University of Florida, United states. My previous educational back ground is in Pharmacy. I did my bachelor in Pharmacy (B.Pharm) from JSS college of Pharmacy, university of Mysore, India and Master of Pharmacy (M.Pharm) from BITS, Pilani, India. I finished my PhD from department of Pharmaceutics, School of Pharmaceutical Sciences, University of Copenhagen, Denmark.
To give you a brief back ground of my expertise, I have 16 years of experience in pre-clinical and clinical development of discovery and development of new chemical entities. I have worked in different parts of the world during my scientific carrier. I worked for several years (2001-2009) with Department of drug metabolism and Pharmacokinetics (DMPK) with Dr.Reddy laboratories Ltd , Hyderabad, India (A major drug discovery and development company) involving pre-clinical and clinical development of new molecules of various class of therapeutic like anti-diabetics, anti-cancer, Anti-infectives, Anti-Inflammatory, lipid lowering agents etc. In 2009 I moved to Denmark to pursue my doctoral studies in School of Pharmacy, university of Copenhagen, Denmark. As a part of my doctoral studies I have worked in the area of drug induced liver injury (DILI) caused by reactive drug metabolites. Later I moved to unites states for my post-doctoral studies with Prof Hartmut derendorf, University of florida. Currently I am working in the area of Bioanalysis, clinical Pharmacology, PK/PD aspects, modelling and simulations. During my scientific carrier I have published more than 20 research articles in international reputed journals and acting as a peer reviewer for some journals.
Bioanalysis: expertise in method development, method validation of compounds by various matrices like plasma, serum, blood and other biological samples by using analytical methods like HPLC, LC-MS/MS, ELISA etc.
ADME studies: Expertise in in vitro (Caco-2 and MDCK, efflux), ex-vivo and in vivo models of absorption. Understanding the distribution of drugs in various tissues by means of cold and radiolabeled compounds. Characterization of drug metabolism in both in vitro and in vivo samples like microsomes, hepatocytes, S9 fractions, tissue slices and in plasma, urine and feces samples. CYP/FMO reaction phenotyping and identifying the enzymes, Metabolite identification and characterization, in vitro and in vivo drug-drug and drug and food interaction studies. Expertise in Mass balance and excretion studies in both pre-clinical and clinical studies.
Toxicology: Expertise in role of reactive drug metabolites in drug induced liver (DILI) or organ toxicity. Reactive oxygen species (ROS), oxidative stress, anti-oxidant defense mechanisms.
Pharmacology: Developing appropriate animal models related to various therapeutic area like anti-diabetic, anti-cancer, hyper-lipidimic, Anti-infectives. Understanding of Pharmacodynamics and Pharmacokinetics of drugs related to above therapeutic classes.
Clinical Pharmacology: Expertise in various phases of clinical development of new drugs. Developing Pharmacodynamics/Pharmacokinetic relations. Drug-Drug, Drug-food interaction studies. Safety and tolerability studies in humans.