Chronic leukemias are a group of malignancies that involves the hematopoietic system and at times the lymphoid system. Chronic leukemias include a variety of diseases. Chronic Myeloid Leukemia (Chronic myelogenous leukemia) also know as CML is a myeloproliferative neoplasm that arises from a clonal process involving early progenitor hematopoietic stem cells and associated with a translocation known as the Philadelphia translocation between chromosomes 9 and 22 leading to the fusion gene BCR-ABL. Another chronic leukemia, which is the most common leukemia in elderly is chronic lymphoid leukemia known as CLL, which can range from and indolent type leukemia/lymphoma to an aggressive form depending on multiple factors including cytogentics.
Post-doctoral researcher, Hematology/ Medical Oncology, NYU Cancer Institute, New York
I have completed my training in Hematology/Medical Oncology at New York University and throughout my fellowship and my post-doctoral research trainings I came to realize how challenging are some types of leukemias including chronic leukemias. Therefore, afterwards I took a path of studying leukemias in the laboratory to discover how fascinating these immortal cancerous cells can be and trying to understand the mechanisms that drive them so we can target in the future. We need to have a better insight into the pathways that lead for the development of leukemias so we can assist in developing novel agents that target the critical steps that lead for leukemogenesis. We should ultimately achieve a higher understanding of the molecular characteristics of the different types of leukemias so we can accomplish treatments targeting these specific pathways in the future. Until then our research and writings about leukemias will continue and even the challenges will never seize our will to overcome them shall always be stronger.