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Advances in Protein Chemistry

Advances in Protein Chemistry

Advances in Protein Chemistry

  • Editor: Dr. Ghulam Md Ashraf   Dr. Ishfaq Ahmed Sheikh  
  • ISBN: 978-1-63278-016-4
  • DOI: 10.4172/978-1-63278-016-4-017
  • No of Pages: 144
  • Publisher: OMICS International
  • Published On: February 2014 , Wed 26
  • Chapter 1      
    The Recent Methodologies of Protein Structural Determination and Dynamic Developments
    Authors: Mahmood H Qazi, Mahmood Rasool, Arif Malik, Abdul Manan, Aamer M Qazi

    Various functions of biological system depend upon the structure and function of proteins. Determination of structure and functions of proteins assist in scrutinizing the dynamics of proteins.

  • Chapter 2      
    Tyrosine Nitrated Proteins: Biochemistry and Pathophysiology
    Authors: Dr. Haseeb Ahsan

    The free radical-mediated damage to proteins results in the modification of amino acid residues, cross-linking of side chains and fragmentation. L-tyrosine and protein bound tyrosine are prone to attack by various mediators and reactive nitrogen intermediates to form 3-nitrotyrosine (3-NT).

  • Chapter 3      
    Advances in Protein Thermodynamics
    Authors: Arif Malik, Mahmood Rasool, Abdul Manan, Aamer Qazi, Mahmood Husain Qazi

    Proteins are synthesized in the cytoplasm or in vitro as amorphous polypeptide chains that, usually, assemble into their functionally active three-dimensional (3D) shapes, a process; known as protein folding.

  • Chapter 4      
    Role of Matrix Metalloproteinases in Cancer
    Authors: Mohd. Afaque Ansari, Sibhghatulla Shaikh, Ghazala Muteeb, Dr.Syed Mohd. Danish Rizvi, Shazi Shakil, Aftab Alam, Rashmi Tripathi, Fauzia Ghazal, Ajijur Rehman, Saeedut Zafar Ali, Anil Kumar Pandey, Ghulam Mohd. Ashraf

    Matrix metalloproteinases (MMPs) are endopeptidases which depend on zinc for their activity. They belong to the metzincin family of enzymes that codes for a highly conserved zinc binding motif.

  • Chapter 5      
    Proteins and Peptides Re-emergence in Prophylactics and Therapeutics
    Authors: Heena Imtiaz Malik, Nazim Husain, Fahim H Khan

    Therapeutic peptides and proteins represent a rapidly growing part of marketed drugs and have an undisputed place alongside other established drugs.

  • Chapter 6      
    New Protein Purification Approaches
    Authors: Waseem Ahmad Siddiqui

    The characterization of proteins and elucidation of its exact biological functions has always been a fascinating task for the researchers.

  • Chapter 7      
    Protein Structure Databases and 3D Structure Prediction Tools
    Authors: Adeel Malik, Ahmad Firoz, Obaid Afzal, Vivekanand Jha, Inho Choi

    Large scale genome sequencing projects are generating tremendous quantity of protein sequences; however, complete understanding of the biological function of these proteins necessitates detailed knowledge about their structure and function.

  • Chapter 8      
    Protein Characterization using Modern Biophysical Techniques
    Authors: Shuja Shafi Malik, Tripti Shrivastava

    Proteins are an important class of macromolecules in living systems that form observable outcome of genetic inheritance or to say are manifestation of genome.

  • Chapter 9      
    New Peptide Based Therapeutic Approaches
    Authors: Riyasat Ali, Richa Rani, Sudhir Kumar

    A large number of chemically well defined and synthetic linear as well as branched therapeutics peptides have been developed and used for a large number of therapeutic applications.

  • Chapter 10      
    Protein Detection Techniques
    Authors: Dennis F Thekkudan

    This review provides a synopsis of some of the more contemporary techniques of studying proteins and peptides. Bottom-up proteomics, as opposed to top-down proteomics, is becoming more common place in protein sequencing.

  • Dr. Ghulam Md Ashraf

    King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia

    Dr. Ghulam Md Ashraf is currently working as an Assistant Professor in King Fahd Medical Research Center (KFMRC) at King Abdulaziz University (KAU), Jeddah, Saudi Arabia. Dr. Ashraf is actively involved in research activities at KFMRC and has been serving as a member of KFMRC Publishing Committee (KPC) since its inception.

    In KFMRC, Dr. Ashraf is actively involved in research and editorial activities. He continues to explore the field of proteomics and structural biology with special emphasis on the role of galectins in cardiovascular and neurodegenerative disorders. Till 2013, Dr. Ashraf has published 18 research manuscripts in internationally reputed journals and many more are under communications. Apart from that, Dr. Ashraf have also written and edited two books and five book chapters. Moving ahead, Dr. Ashraf is determined to give his best in terms of good science and strive hard for his contribution towards the betterment of society.

     

  • Dr. Ishfaq Ahmed Sheikh

    King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia

    Dr. Sheikh continues to explore different related areas of his research with the ultimate goal for the superior good of the society. His goal is to target prevalent diseases of Saudi Arabia. He wants to reap the combined benefits of his Doctoral (Strucural Biology) and Postdoctoral (Cancer Biology) studies and integrate them towards the treatment of these diseases by designing inhibitors which can be potential drugs. He would adopt Structural (Crystallographic, computational and other biophysical) and Proteomics approaches for these studies.

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