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Advances in Neurotherapeutic Delivery Technologies

Advances in Neurotherapeutic Delivery Technologies

Advances in Neurotherapeutic Delivery Technologies

  • Editor: Mr. Pradeep Kumar   Prof. Viness Pillay   Prof. Yahya E. Choonara  
  • ISBN: 978-1-63278-036-2
  • DOI: 10.4172/978-1-63278-036-2-037
  • No of Pages: 183
  • Publisher: OMICS International
  • Published On: March 2015 , Fri 20
  • Chapter 1      
    Current Treatment Dilemmas in Neurological Disorders
    Authors: Girish Modi, Eitsaz Sadiq, Kalpesh Jivan

    Diseases of the nervous system range from the paroxysmal disorders, namely epilepsy, migraine and the affective illnesses to the degenerative disorders including Alzheimer’s disease, Parkinson's disease and Motor neurone disease.

  • Chapter 2      
    Formulation and Pharmacological Factors for Enhanced Neuro Therapeutic Bioavailability
    Authors: Yashwant Pathak, Rohini Nimbalkar, Charles Preuss

    This chapter reviews and discusses the formulation and pharmacological factors that could lead to enhanced bioavailability of the drugs in the central nervous system.

  • Chapter 3      
    Transport Mechanisms of Neurotherapeutics across the Blood-Brain Barrier
    Authors: Kalpana Nagpal, Sourav Thakur

    The delivery of neurotherapeutics to CNS is prevented mainly by the Blood Brain Barrier (BBB) and Blood Cerebrospinal Fluid Barrier (BCSFB).

  • Chapter 4      
    NanoVectors for Neurotherapeutic Delivery Part I: Liposomes and Micelles
    Authors: Tansel Comoglu, Fatemeh Bahadori

    Neurotherapeutic nano-liposomal and micellar formulations will be discussed in this chapter.

  • Chapter 5      
    Nanovectors for Neurotherapeutic Delivery Part II: Polymeric Nanoparticles
    Authors: Claudio Salomon, Carl Simonsson, Guillaume Bastiat, Marion Pitorre

    The term “nanomedicine” was introduced about 10 years ago as a consequence of an increasing association between physico-chemistry of nano-assemblies and pharmaceutical and medical sciences.

  • Chapter 6      
    Nose-to-Brain Neurotherapeutic Interventions
    Authors: Pradeep Kumar, Olufemi D Akilo, Viness Pillay

    The delivery of drugs to the brain has been fraught with low bioavailability of drugs in the brain.

  • Chapter 7      
    Molecular Trojan Horses as Genomic Interventions in Neurotherapeutics
    Authors: Riaz A. Khan, Nahid Abbas

    Blood supplies to the brain are through tightly packed cell layers that form a physical barrier, commonly known as Blood Brain Barrier (BBB).

  • Chapter 8      
    Convection-Enhanced Delivery of Neurotherapeutics
    Authors: Valence MK Ndesendo

    The delivery of therapeutic drugs to the brain is a challenging task despite the fact that brain is highly accessible for other substances like nutrients and oxygen.

  • Chapter 9      
    Nano-Strategies for Neuro-Imaging and Diagnostics
    Authors: Seema Nara, Manisha Sachan, Satish Malik

    Nanotechnology has found great potential in medical diagnostics and imaging and their applications in the field of neuroscience are a focus of recent research.

  • Chapter 10      
    Recent Developments in the Microemulsion Based Targeted Delivery of Neurotherapeutics
    Authors: Vikas Rana, Kuldeep Singh, Sunil Kamboj Kamboj

    Brain diseases are associated with disorders of psychiatric and neurological disturbances. They afflict a very significant portion of the population, right across the life span and are prevalent in both developed and developing countries.

  • Mr. Pradeep Kumar

    Faculty of Health Sciences, University of the Witwatersrand

    Mr. Pradeep Kumar is a Lecturer of Pharmaceutics and a doctoral research candidate under the mentorship of Viness Pillay within the Department of Pharmacy and Pharmacology at the University of the Witwatersrand, Johannesburg, South Africa. His research is focused on computational simulations and macromolecular bioactive release from polymer engineered neural devices in vivo for spinal cord injury interventions. He has several peer-reviewed publications to his credit that include book chapters, research papers and reviews.

  • Prof. Viness Pillay

    Faculty of Health Sciences, University of the Witwatersrand

    Professor Viness Pillay, a Fulbright Scholar and Fellow of the African Academy of Sciences (AAS), is a South African National Research Foundation (NRF) Research Chair in Pharmaceutical Biomaterials and Polymer-Engineered Drug Delivery Technologies at the University of the Witwatersrand (Wits), Johannesburg, South Africa. He is also the recipient of the Olesugun Obasanjo Prize 2014 for Scientific Breakthrough and Innovation in Advanced Drug Delivery Technologies and Director of the Wits Advanced Drug Delivery Platform (WADDP) Research Unit (http://www.wits.ac.za/waddp). The WADDP is the only Platform in its domain in South Africa that encompasses the research, development and commercialization of innovative prototypes in the area of neurotherapeutic delivery technologies under development by his research team. Prof. Pillay currently has several granted international patent applications and his research has been extensively published in international peer-reviewed journals, with vast contributions to editorials, books and book chapters as well as presentations at local and international conferences in the areas of pharmaceutical drug delivery technology, neurotherapeutics and polymer science. He currently serves on the Reviewer, Editorial Advisory Board and Lead Guest Editor of several international scientific journals and books.

  • Prof. Yahya E. Choonara

    Faculty of Health Sciences, University of the Witwatersrand

    Prof. Yahya E. Choonara is an Associate Professor of Pharmaceutics in the Department of Pharmacy and Pharmacology at the University of the Witwatersrand, Johannesburg, South Africa. He is also the Research Manager of the Wits Advanced Drug Delivery Platform (WADDP) Research Unit and a Founding Board Member of the South African Young Academy of Science (SAYAS) as well as an elected Young Affiliate to The World Academy of Sciences (TWAS). His research is focused on advancing drug delivery systems by merging In Silico Computational Modeling Theories to blueprint drug delivery technologies with ‘smart’ capabilities beyond what has been achieved thus far for treating hereditary disorders and lifestyle diseases. His research has been widely published in ISI-recognized scientific journals. He is also a co-inventor of several international patents and is frequently called upon as an Expert Reviewer for international journals, peer-reviewed conferences and research funding institutions.

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