Advanced Techniques in Biology & Medicine
Open Access

Anja Nohe

Research Interest

Her Research interest is in Development of Delivery Techniques. Current research is limited in tools to transfect proteins into cells, especially the cell nucleus. We recently developed a new very efficient transfection technique for proteins and nanoparticles into the cell nucleus. Our method provides 70-80 percent transfection efficiency of primary cells and cell lines. The uptake is very rapidly, cells stay alive for at least 3 days. Studies show that the method is non invasive, making it a powerful transfection tool. We are currently working on the detailed mechanism of the delivery. Development of New Imaging Techniques. In order to study signal transduction in real time in live cells new imaging tools must be developed. One major goal of my research focuses on the further development of the Family of Image Correlation Spectroscopy (FICS), a powerful tool to measure protein dynamics, aggregation and signalling. Differentiation of Stem Cells: Role of Hormones and Growth factors. In general my laboratory is interested in determining molecular dynamics underlying stem cell differentiation. In detail I am interested in developing new imaging techniques and probes to study real time dynamics of signal transduction mechanisms. We are especially interested to develop new probes and delivery techniques and use these approaches to investigate the influence of nanoscale receptor dynamics underlying diseases such as cancer and osteoporosis.

Relevant Topics