Home  |  Publications  |  Conferences   |  Join  |  Contact
                           
 
ISSN: 2329-9002

Journal of Phylogenetics & Evolutionary Biology

Open Access
 
 
OMICS International organises 1000+ Conferences every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes
700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
 
 
 
 
 
 
Research Article Open Access
Evolutionary Interrelationships and Insights into Molecular Mechanisms of Functional Divergence: An Analysis of Neuronal Calcium Sensor Proteins

Jeffrey Viviano, Hao Wu and Venkat Venkataraman

Abstract

The normal function of any organism, its organizational complexity notwithstanding, depends on the interaction of its proteins with their targets. Thus, analysis of target site interaction is an essential part of all biology. At the protein level, such analyses are critical to both mechanistic knowledge and potential clinical applications such as drug discovery. Approaches to map amino acid residues involved in target site interaction typically are experimental or based on three-dimensional structures obtained through crystallography. Here we test a novel approach that combines phylogenetic analyses with mining of experimental data using neuronal calcium sensor proteins. The proteins fall into three groups based on sequence comparison. One interaction was taken up for analysis from each group. Using the sequence divergence to evaluate the role of amino acids identified experimentally to form the interface with the target, we demonstrate that it is possible to predict residues that are likely to contribute to the specificity of the interaction and, therefore, the functional divergence. Thus, evolutionary analyses of proteins provide an important addition in approaches to generate refined maps of target site interactions in proteins. This approach is especially useful in delineating the functional divergence in a family of closely related proteins.

Keywords

Functional | divergence | Evolution | Neuronal | calcium | sensor | proteins | Guanylate | cyclase | GCAP | KChIP | VILIP | 

Special Features

image  Download PDF
image  Full-Text HTML
image  Language Translation
 
 
 
OMICS International Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
 
 
OMICS International Conferences 2015-16
 
Meet Inspiring Speakers and Experts at our 1000+ Global Annual Meetings
 
 

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@openaccessjournals.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@openaccessjournals.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@openaccessjournals.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@openaccessjournals.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

agrifoodaquavet@openaccessjournals.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@openaccessjournals.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@openaccessjournals.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@openaccessjournals.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@openaccessjournals.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@openaccessjournals.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@openaccessjournals.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@openaccessjournals.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@openaccessjournals.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@openaccessjournals.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@openaccessjournals.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@openaccessjournals.com

1-702-714-7001 Extn: 9042

 
© 2008-2015 OMICS Group - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version