Department of Biochemistry & Molecular Medicine
The George Washington University
Dr. Kim is an Assistant Professor in the Department of Biochemistry and Molecular Medicine at the George Washington University Medical Center. He earned his PhD degree in Molecular Genetics from the University of Wisconsin, Madison, WI, and completed his postdoctoral research in Yeast Genetics and Molecular Biology at Washington University, St. Louis, MO. He had a faculty position at the University of Southern Mississippi.
Most organisms have evolved numerous regulatory mechanisms for sensing glucose and utilizing it efficiently. Glucose sensing and signaling in yeast remains an important paradigm for understanding molecular mechanisms that link extracellular signals to changes in an organism’s transcriptional program. The lab investigates the molecular basis of the crosstalk between the three major glucose signaling pathways in yeast—Rgt2-Snf3, Snf1 (AMPK)-Mig1, and cAMP-PKA, with the aim of understanding how they are integrated into a regulatory circuit to properly control the rate of glucose uptake, the first-rate limiting step for glucose metabolism. Understanding this crosstalk is likely to have a significant impact on our understanding of the processes involved in the maintenance of glucose homeostasis in humans, especially under pathological conditions, such as hyperglycemia in diabetics and the elevated rate of glycolysis observed in many solid tumors.
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